Is the vaccine still effective in the face of new coronavirus mutants?

“Click 👆 Key words: covid-19; vaccine; mutant human beings have been on guard against the failure of the original vaccine caused by the mutant strain of new coronavirus while accelerating the vaccination of new coronavirus

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Scholars have given the current answer through scientific research

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1

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New England Journal of Medicine: validation of Pfizer mRNA vaccine on March 8, 2021, New England Journal of Medicine (NEJM) published one of a series of important studies on UTMB mutants, which selected 15 vaccinated sera 2 or 4 weeks after the second bnt162b2 vaccination

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The results showed that the neutralizing activity (prnt50gmt) of the serum against wild type usa-wa1, b.1.1.7 (British variant), P.1 (Brazilian variant), b.1.351 (South African variant), b.1.351 – △ 242-244 / d614g and b.1.351-rbd / d614g were 532663437194485 and 331, respectively

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Compared with neutralizing usa-wa1, the activity of neutralizing b.1.1.7 and P.1 was almost the same, but the activity of neutralizing b.1.351 was decreased, but still significantly inhibited the virus

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The resistance of k417n, e484k and n501y to vaccine induced neutralizing serum was higher than that of NTD and △ 242-244

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(photo source: Reference 1) 2, nature: verify the two mRNA vaccines

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On March 7, 2021, the article of he Dayi group of ADARC on the resistance of antibody to b.1.351 and b.1.1.7 mutants was officially launched in nature

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It was found that b.1.1.7 could escape most NTD antibodies and a few RBD antibodies, while b.1.351 could resist most NTD and RBD antibodies because of its e484k mutation

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The neutralization activity of plasma to b.1.351 was reduced by 9.4 times, and the neutralization activity of serum inoculated with Moderna and Pfizer vaccine to b.1.351 was reduced by 10.3-12.4 times

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(source: reference 2) 3

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Natural immunology: T cell immune response of convalescent patients with novel coronavirus lasts for at least 6 months

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On March 5, 2021, natural immunology published a study of the University of Birmingham, UK, which analyzed the T cell response of 100 patients infected with sars-cov-2 after 6 months of infection

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The most important phenotypes of these patients were significant CD4 T cell response and large amount of IL-2 expression

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Interestingly, the T cell response in symptomatic patients was more than 50% higher than that in asymptomatic patients

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This suggests that the severity of the initial infection establishes a “set point” for cellular immunity

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There was a positive correlation between the specific response of T cells to s and N antigens and the peak titer of antibodies, especially between the specific response of T cells to n antigens and the persistence of specific antibodies to n antigens

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This study demonstrates that sars-cov-2 specific T cell responses can persist for at least six months after infection

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(source: ref

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3) but at present, the key is rapid vaccination

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The mutation of the new coronavirus is produced in the process of transmission

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Only through vaccination as soon as possible to reduce the spread of the virus, in order to reduce the chance of mutation

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Vaccination is advancing rapidly

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In this case, all countries with access to vaccines are making every effort to promote vaccination

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As of March 10, 2021 EDT, 121 countries around the world have started vaccination, with more than 326 million doses, and 8.35 million doses of vaccine have been injected every day, according to the news from Bloomberg

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The fastest vaccination rate was mainly in the countries with the most serious epidemic

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As shown in the figure below, Israel, North America and European countries are relatively ahead in vaccination coverage

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(global novel coronavirus vaccination map

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Photo source: Peng Bo) two countries have received more than 50 million doses of vaccination, namely, the United States and China

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The race to end the epidemic

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Screenshot source: Peng Bo) since December 14, the United States has opened vaccination registration among medical staff, and has received 95.72 million doses

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At present, 18.8% of the population has completed more than one dose of vaccination

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The vaccines were obtained from Pfizer / biontech company, Moderna company and Johnson & Johnson company

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In the recent week, the number of single day vaccinations in the United States has been more than 2 million doses per day

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In a recent public speech, US President Biden promised that by the end of May, all adults in the United States who are willing to be vaccinated will be vaccinated

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If the current vaccination rate remains unchanged, the United States will complete the mass immunization in six months

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Novavax’s protein vaccine is expected to come on the market in April, thus speeding up vaccination

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China has received 52.5 million doses, accounting for 3.75% of the population, mainly inactivated virus vaccines from Sinopharm group and Kexing, and adenovirus vaccines from kangxinuo / Academy of Military Sciences

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In the recent week, the number of inoculations per day in China was about 600000, while the number of inoculations per day at the peak was 1.5 million

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In addition to the above-mentioned two countries, Israel has received 9.05 million doses of vaccine, 56% of the population has received at least one dose of vaccine; it is currently the country with the highest proportion of novel coronavirus vaccination

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Real world studies in Israel show that the effectiveness of the vaccine in preventing symptomatic sars-cov-2 infection is as high as 94% seven days after the second vaccination, and it can significantly reduce the hospitalization rate and mortality rate, thus verifying the effect of the vaccine and bringing hope and comfort to countries all over the world

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reference: https://www.nejm.org/doi/full/10.1056/NEJMc2102017https :// www.nature.com/articles/s41586-021-03398-2https :// www.nature.com/articles/s41590-021-00902-8.pdf Editor: Henry, micro signal, healsan

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Introduction: Hanson clinical research team is composed of 6 doctors and medical scientists in the United States

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Three of them have presided over the National Natural Science Foundation in China, and are mainly engaged in new drug research and clinical research in the United States

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