Self report of a new vaccine

I am a new inactivated coronavirus vaccine, born in the critical moment of the epidemic, carrying the ardent hope to overcome the virus, is currently being mass vaccinated by mankind! Have you vaccinated me? Do you know my “past life and present life”? My previous life was a New Coronavirus with a diameter of about 100 nm

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At the end of 2019, I began to appear in the human eye

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I kept replicating myself, creating an evil army of viruses, attacking cities and lands all over the world

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Tens of millions of people were infected and millions died

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Scientists isolated me from the patient and named the disease I caused as cowid-19

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Kexing staff show New Coronavirus model

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Scientists have been working day and night to tackle key problems urgently and have carried out intensive research on me in the laboratory

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They cultured me in Vero cells and selected a strain suitable for vaccine preparation, CZ strain

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From then on, I broke with my virus family and embarked on the road of helping mankind fight against the epidemic

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The staff received the new coronavirus strain for vaccine production from Zhejiang Province at the China Center for Disease Control and prevention

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In the vaccine production workshop, from “inoculation” to “birth”, I have to go through six steps: cultivation, inactivation, purification, proportioning, filling and packaging

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Vero cells were cultured in a cell factory (early laboratory process)

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A large number of new coronavirus must be propagated in order to prepare inactivated vaccine of new coronavirus

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Scientists isolated and cultured Vero cells from kidney epithelial cells of African green monkeys

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It can be divided for many times without aging

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It is the most suitable “soil” for my reproduction

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The staff checked the reactor setting parameters during the trial operation

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The staff took samples from the original solution workshop of Kexing Zhongwei Xinguan vaccine for testing Vero cell culture

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Objective to investigate the status of Vero cells cultured on microcarriers in Kexing Zhongwei bioreactor under microscope

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I was placed in an isolator and injected through a closed tube into a bioreactor full of Vero cells

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I quietly here rapid propagation, a few days later, has spawned countless brothers and sisters

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In the high-level biosafety protection zone of the original solution workshop of Kexing Zhongwei Xinguan vaccine, the staff simulated the inoculation operation of new coronavirus before putting into production

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Together, we went through a closed tube to another bioreactor

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A special inactivator was injected, which made me lose consciousness and fall asleep A few hours later, I woke up from my sleep and suddenly found that I had completely lost the pathogenicity and could not reproduce and grow

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At this time, I became an inactivated liquid

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The staff of the inactivation tank in the high-level biosafety protection zone of the original solution workshop of Kexing Zhongwei Xinguan vaccine inspected the trial operation of the equipment before it was put into operation

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Then I came to the hut in the purification area

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Through all kinds of sieves and pipes, I was gradually concentrated, and inactivators and other impurities were gradually removed

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At this time, I have a new identity – vaccine stock

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In the purification area of Zhongwei Xinguan vaccine stock solution workshop of Kexing, the staff carried out operation drills before putting into production

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In the vaccine proportioning area, the staff mixed me with adjuvant and diluent, and I became a semi-finished vaccine, and went into the cold storage to wait for inspection

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The staff worked in the new vaccine mixing room

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Staff prepare silica gel pipe in preparation workshop

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In order to make it easy to use, people have designed two kinds of packaging for me – one is a bottle of penicillin

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Before I live in, each vial has to go through the process of ultrasonic pre cleaning, high temperature steam condensate washing, compressed air injection, 350 ℃ high temperature drying and so on

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On the aseptic filling line, I was quickly injected into small bottles by the machine, and then sealed with rubber stoppers and caps

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Staff in the preparation workshop to check the operation of the vial automatic cleaning machine and the tunnel oven

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The staff checked the new vaccine label on the automatic vial packaging line

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The staff showed the new vaccine packed in vials in the packaging workshop

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One is a pre filled syringe

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The robot arm operates in a sterile environment

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When I enter the syringe, the machine is plugged and sealed, and I am isolated from the world

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The staff checked the on-line monitoring data of filling volume in the filling workshop of pre filled syringe dosage form

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Kexing Zhongwei automatic packaging line is used to install push rod for new coronal vaccine of pre filled syringe dosage form

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Kexing Zhongwei automatic pre filling syringe dosage form novel coronavirus vaccine packaging line

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The staff checked the label of the prefilled syringe dosage form of the novel coronavirus vaccine

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In the packaging line, light inspection is the biggest test for me

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The camera takes pictures for me at different angles and under different background light to ensure that I am not mixed with impurities in the bottle, the position of the sealing plug is accurate, and the bottle body is not scratched

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If I am not perfect, I will be expelled here

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The staff work next to the automatic light inspection machine in the packaging workshop

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In the packaging workshop, the staff carried out manual sampling inspection on the novel coronavirus vaccine after passing the lamp inspection of the automatic lamp inspection machine

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Next, I was labeled with the name and batch number of the product, and packed into a small box with a manual

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Each packing box is also printed with an exclusive traceability code

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When I produced it, where I was sent and who was vaccinated can be found quickly through this number

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Automatic packaging line for novel coronavirus vaccine drug traceability supervision code

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