About the novel coronavirus vaccine, the second injection has not been given within the time limit, but the first one has been given in vain?

Recently, as people’s willingness to get the new coronavirus vaccine continues to rise, many people begin to worry about whether the first dose of vaccine will be wasted if the second dose of vaccine can not be vaccinated on time? Can the new coronavirus vaccine be vaccinated with other vaccines? How long is the best interval? Around these hot topics, sun Limei, director of the Institute of immunization of Guangdong CDC, responded that delaying vaccination generally does not affect the immune effect

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According to the technical guidelines for new coronavirus vaccination (First Edition) (hereinafter referred to as the technical guidelines), the interval between two doses of inactivated new coronavirus vaccine is recommended to be greater than or equal to 3 weeks (21 days), and the second dose should be completed as soon as possible within 8 weeks (56 days)

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How to determine the interval of vaccination“ The interval between doses of the same vaccine is determined according to the results of strict clinical trials before marketing, and these intervals have sufficient scientific basis

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” Sun Limei said that the interval between the two doses of the new coronavirus inactivated vaccine is determined according to the clinical trial data and the results of the relevant monitoring data of the early population after vaccination

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It is mainly based on the antibody production after vaccination to determine the number of doses and the time interval between each dose to achieve the disease prevention effect“ According to the previously published literature on inactivated new coronavirus vaccine, a second dose of inactivated new coronavirus vaccine at an interval of 4 weeks can produce better immune effect in the recipients Sun said

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Recently, due to the shortage of vaccine supply, many people worry that the second dose of vaccine can not be vaccinated on time, which will affect the immune effect

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In this regard, sun Limei said, according to the current evidence-based analysis, delayed vaccination generally does not affect the immune effect

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If two doses of vaccination can not be completed within the time interval required by the procedure, the vaccination should be conducted as soon as possible

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The immunization procedure does not need to be restarted, and the corresponding dose can be completed“ If you get the first shot of the new coronavirus inactivated vaccine, but the second shot is not vaccinated on time according to the procedure, then you can get the second shot as soon as possible

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” Sun Limei explained

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The interval between two doses of new coronavirus vaccine has been adjusted, from 28 days recommended in the first batch to 56 days in the technical guidelines

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Will longer vaccination interval affect vaccination effect? In response, Sun Limei novel coronavirus pneumonia vaccine, the two time interval between the two groups, was approved by experts from the National Immunization Program Expert Committee

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It was determined based on the clinical trial data of the approved vaccine and the epidemiological characteristics of the novel coronavirus pneumonia

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The results of the study were as follows: (1) the vaccine is recommended by the National Advisory Committee of experts on immunization

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The results of the study are based on the data of the clinical trials of the approved vaccine and the epidemiological characteristics of the novel coronavirus pneumonia

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Sun Limei Each kind of vaccination has a specific immune procedure, following the immune procedure can ensure that the recipients get better immune effect

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Interval vaccination with other vaccines is convenient to distinguish adverse reactions

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Can new coronavirus vaccine be inoculated with other vaccines at the same time《 According to the technical guidelines, it is not recommended to vaccinate the new coronavirus vaccine with other vaccines at the same time

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Sun Limei said that due to the short time of conditional approval of the new coronavirus vaccine, it is not allowed to be inoculated with other vaccines at the same time, in order to identify and distinguish the possible abnormal reaction of the suspected vaccination

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According to the results of the previous clinical trials and the information collected during the emergency use of the new coronavirus vaccine, the occurrence of common adverse reactions of the new coronavirus inactivated vaccine is basically similar to that of other widely used inactivated vaccines

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According to sun Limei, the common adverse reactions of inactivated vaccines are mainly manifested as swelling, induration, pain, etc

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at the inoculation site, as well as clinical manifestations such as fever, fatigue, nausea, headache, muscle soreness, etc

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most of them will appear and be relieved within 14 days“ So generally speaking, it is recommended that the interval between the new coronavirus vaccine and other vaccines should be at least two weeks Sun Limei said that by doing so, the adverse reactions of the new coronavirus vaccine can be distinguished from those of other vaccines, which is more conducive to the collection of data on the safety of the new coronavirus vaccine, and is conducive to the follow-up comprehensive and systematic safety assessment

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However, sun Limei reminded that if rabies vaccine, tetanus vaccine and immunoglobulin should be injected due to animal injury, trauma and other reasons, they can be vaccinated at the same time as the new coronavirus vaccine, regardless of the time interval“ In fact, such regulations are also based on the consideration of timely treatment of major injuries, prevention of serious diseases and protection of life and health

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” Sun Limei said that rabies is a fatal disease, the death rate after the onset of almost 100%

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The only way of prevention is to vaccinate human rabies vaccine as soon as possible after animal injury and exposure

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In case of conflict with other vaccination time, priority should be given to the vaccination of human rabies vaccine

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Similarly, tetanus is a very serious disease with high mortality

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People who are seriously injured should also be vaccinated against tetanus in time

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There are also answers to the following questions: what happens if you don’t get a second dose? A: the determination of vaccine immunization procedures is based on the results of research and development stage and clinical trial stage, so as to obtain the best safety, immune response effect and immune persistence

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It is difficult to obtain the best immune response effect and immune persistence without complete vaccination

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So it is suggested that we must complete the complete vaccination according to the formal process

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Is it safe to replace the second dose with vaccine from other manufacturers? A: in principle, it is safe

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For some reason, the same kind of vaccine cannot be used to complete the vaccination, and the vaccine products of other manufacturers of the same kind can be used to complete the vaccination, but we must pay attention to the premise: it must be the same kind

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Is there any difference in composition and dose between two injections of novel coronavirus vaccine? A: according to the current immunization strategy, there is no difference in the composition and dose between the first and second doses of the novel coronavirus vaccine

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Can the second dose be vaccinated in advance? A: the best time to vaccinate the novel coronavirus vaccine is 21 days between two injections

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If the interval is shortened to 14 days or extended to 28 days, the neutralizing antibody titer is lower, but it is basically an order of magnitude, and there may not be much difference in the actual effective rate

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However, if the two injections are given together, the neutralizing antibody titer is very low and may not play a protective role

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Will the second dose be more severe? A: it depends

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  The role of the second dose of the novel coronavirus vaccine is to ensure that the vaccine can strengthen the immune function of the human body, because everyone’s constitution is different, so the reaction to the second dose is also different

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Some people may have a greater reaction, and some people may have a reduced reaction

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  But generally speaking, these adverse reactions are within the safe and acceptable range

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After the second injection, it is recommended to observe in the observation area for 30 minutes

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If the adverse reactions are serious, it is recommended to report to the vaccination institution in time, and cooperate with the relevant staff to make records

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Is it not successful that there is no response after vaccination? A: not really

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  According to the published data, the antibody positive rate can reach 60% – 90% after the first dose of Xinguan vaccine according to relevant regulations, and the antibody positive rate can reach 97% after 28 days of the second dose, and it can form continuous protection for more than 6 months, so it is generally successful

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  In this regard, Yu Wenzhou, chief physician of the center for immunization planning of the Chinese Center for Disease Control and prevention, said that after vaccination, antibodies will naturally occur

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Generally, after the second dose of vaccine is vaccinated for about two weeks, the antibodies will reach the peak

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If it is unnecessary, it is not recommended to test the vaccinators for antibodies

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Follow me here to see more local information of Qidong source: Southern +, Guangdong health information, grassroots doctors’ Commune  | Editor: today’s open network – YY leaders say praise and flowers on the reward Xiaobian 5 cents.

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