Contents of popular science propaganda and education on new coronavirus vaccination

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Wearing masks / non gathering / washing hands / novel coronaviruss vaccine immunization contents, 1

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The necessity of COVID-19 vaccination

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COVID-19 is still at a high level of pandemic epidemic in the world

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The risk of local spread of the disease is still persisting from abroad

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By the end of April 18th, the total number of 190 million doses of COVID-19 vaccine has been vaccinated in the whole country

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To reach the target of group immunity, it needs about 1 billion

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At present, the vast majority of people have no immunity against the new coronavirus

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After infection, some people will develop into critical illness or even death

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The number of people who have been fully vaccinated with the novel coronavirus vaccine in the United States has reached 32.5% of the total population

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If all countries have completed the vaccination, and the domestic vaccination rate can not be increased, it will be very dangerous

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Vaccination is the most effective and economical way to prevent and control the epidemic situation

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Vaccination is the responsibility and obligation of every citizen

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On the one hand novel coronavirus pneumonia can effectively reduce the risk of morbidity, severe and death after inoculation

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On the other hand, by inoculating COVID-19 vaccine in an orderly way, we can gradually establish an immune barrier in the population, block the prevalence of novel coronavirus pneumonia, and restore the domestic economy and the normal operation of the residents as soon as possible

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At present, the new coronavirus vaccines of five manufacturers in China have been approved for conditional marketing or emergency use, among which three inactivated vaccines and one adenovirus vector vaccine have been approved for conditional marketing; in addition, one recombinant new coronavirus vaccine (CHO cell) has been approved for emergency use

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The three new coronavirus inactivated vaccine products approved for marketing conditionally are respectively produced by Sinopharm China biological Beijing Biological Products Research Co., Ltd

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(Beijing Institute), Wuhan Biological Products Research Institute Co., Ltd

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(Wuhan Institute) and Beijing Kexing Zhongwei Biological Technology Co., Ltd

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(Kexing Zhongwei)

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Two doses are required

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The interval between the first dose and the second dose should be more than 3 weeks, and the second dose should be completed as early as 8 weeks after the first dose

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The conditionally approved adenovirus vector vaccine is produced by kangxinuo biological Co., Ltd

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One dose is required

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The recombinant subunit vaccine approved for emergency use is produced by Anhui zhifeilongkema biopharmaceutical Co., Ltd

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The interval between the first dose and the second dose, the interval between the second dose and the third dose should be more than 4 weeks

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The second dose should be completed within 8 weeks after the first dose, and the third dose should be completed within 6 months after the first dose

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3、 The new coronavirus vaccine, like other vaccines, has gone through animal experiments, human pre-test experiments, population phase I / II and phase III clinical trials before marketing

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The safety of the vaccine has been verified many times

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At present, the new coronavirus vaccines on the domestic market have been reviewed and approved by the competent government departments, which are safe and effective, and are uniformly distributed by the provincial CDC departments

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It is not recommended that individuals choose the type of vaccines on their own

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At present, the target population of NCV vaccination in China is 18 years old and above (local residents, employees of enterprises and institutions, permanent residents, teachers and students, etc.)

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Vaccination adhere to the principle of informed consent, voluntary and free vaccination, among which the party and government organs, enterprises and institutions, colleges and universities, medical and health institutions and other personnel to achieve “should receive as much as possible.”

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People over 60 years old are at high risk of severe and death after new coronavirus infection

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At present, the number of phase III clinical trials of four new coronavirus vaccines approved for marketing is limited

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The phase III trial of recombinant subunit vaccine is still in progress, and there is no data on the protective effect of the vaccine on this population

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However, the data of phase I / II clinical study of the above vaccine showed that the safety of vaccination was good

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Compared with the population aged 18-59, the titer of neutralizing antibody was slightly lower after vaccination, but the positive conversion rate of neutralizing antibody was similar, suggesting that the vaccine would also have a certain protective effect on the population aged over 60, so vaccination is recommended

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For women of childbearing age who are pregnant after vaccination or have been vaccinated in the case of unknown pregnancy, based on the understanding of the safety of the vaccine, it is not recommended to take special medical measures (such as termination of pregnancy) only because of the vaccination of new coronavirus vaccine, and it is recommended to do a good job in pregnancy examination and follow-up

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For women who have a pregnancy plan, it is not necessary to delay the pregnancy plan just because of the new coronavirus vaccine

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However, based on the understanding of the safety of the vaccine, it is recommended to vaccinate lactating women (such as medical staff) with high risk of new coronavirus infection

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Considering the importance of breast-feeding to infant nutrition and health, referring to the international practice, it is suggested that breast-feeding should be continued after breast-feeding women are vaccinated with new coronavirus vaccine

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4、 The new coronavirus vaccine is usually not vaccinated

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The contraindication of vaccination refers to the situation that should not be vaccinated

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According to the technical guidelines for new coronavirus vaccination (First Edition), the general vaccination contraindications include: 1

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People who are allergic to the active ingredients, any non active ingredients and substances used in the production process of the vaccine, or those who have been allergic to the same kind of vaccine before; 2

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People who have had severe allergic reaction to the vaccine in the past (such as acute allergic reaction, vascular and nervous water) 3

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Patients with uncontrolled epilepsy and other serious nervous system diseases (such as transverse myelitis, Guillain Barre syndrome, demyelinating disease, etc.); 4

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Patients with fever, acute or chronic diseases, or uncontrolled severe chronic diseases; 5

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Pregnant women

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Some taboos, such as fever, are temporary

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When the situation leading to taboos no longer exists, vaccination can be given later

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5、 Vaccination of patients with common chronic diseases with new coronavirus vaccine 1

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Allergic rhinitis

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The contraindications in the vaccine instructions include: severe allergic reactions (such as acute allergic reaction, urticaria, skin eczema, dyspnea, angioneurotic edema, abdominal pain) in the past should not be vaccinated

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Therefore, we should consider the severity of allergic constitution and follow the doctor’s advice

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Gout attack period

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The contraindications in the vaccine instructions include all severe acute and chronic diseases in acute attack period, so it is not suitable to vaccinate in gout attack period

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High blood pressure

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The contraindications in the vaccine instructions include: severe liver and kidney diseases, drug uncontrollable hypertension (systolic blood pressure ≥ 140mmHg, diastolic blood pressure ≥ 90mmHg), diabetic complications and malignant tumor

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Therefore, according to the requirements of the instructions, the new coronavirus vaccine should not be vaccinated against the drug uncontrolled hypertension

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However, patients with hypertension can be vaccinated with new coronavirus vaccine in principle under the condition that the drug maintains normal blood pressure

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Please follow the doctor’s advice for details

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Diabetes

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The instructions of the vaccine require that patients with severe liver and kidney diseases, uncontrollable hypertension, diabetic complications and malignant tumors should not be vaccinated with new coronavirus vaccine

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However, diabetic patients without complications do not belong to the scope of contraindication, please follow the doctor’s advice

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Heart disease

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The contraindications in the vaccine instructions include fever, various acute diseases, acute attack of chronic diseases, and the vaccination is postponed

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Therefore, if heart disease, coronary heart disease and coronary atherosclerosis are in acute attack stage, vaccination should be postponed

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Patients with chronic diseases, in the case of good drug control, in principle, can be vaccinated, please refer to the doctor’s advice

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Impaired immune function (malignant tumor, nephrotic syndrome, AIDS patients, etc.)

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The immune response and protective effect of these people may be reduced after vaccination.

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