How to choose a single or double dose of Xinguan vaccine?

At present, the overseas epidemic situation is still serious, and the domestic epidemic situation has been effectively controlled

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In the choice of new coronavirus vaccine, many people have encountered the “choice of trouble”: do you want to get a vaccine? Which kind of vaccine is better? How to choose single needle and double needle? At present, four new coronavirus vaccines have been approved by the State Food and drug administration

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According to the technical route, there are two categories: one is inactivated vaccine, including three inactivated vaccines produced by Sinopharm Beijing company, Sinopharm Wuhan company and Beijing Kexing Zhongwei company; the other is adenovirus vector vaccine, type 5 adenovirus vector vaccine produced by Tianjin kangxinuo company

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Which is better? The competent department of the National Health Commission said that no matter what kind of technical route is adopted, as long as the vaccine has been officially approved by the state, its safety and effectiveness are supported by certain data, and the potential benefits or known benefits are greater than the potential risks or known risks, so the public can be assured to choose

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Industry experts said that the two new coronavirus vaccines have their own characteristics

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Shao Yiming, a researcher of China CDC and consultant of who vaccine R & D Committee, said that the inactivated vaccine is to culture and amplify the new coronavirus, kill it, and then inject the inactivated virus particles into the human body to induce an immune response

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Because inactivation will destroy some protein antigens on the surface of the virus, the immunogenicity of the vaccine is lower than that of the live virus

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The first injection induces memory cells, and the second injection stimulates the memory response to enhance the overall immune response exponentially

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Wang Junzhi, deputy leader of vaccine research and development team of scientific research group and academician of Chinese Academy of engineering, said that the main characteristics of inactivated vaccine are that the composition of vaccine is close to the structure of natural virus, and the immune response is usually strong, which has good safety

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The vaccine is stable and can be stored for two to three years at 2 to 8 degrees Celsius

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And adenovirus vector vaccine is like a car carrying the cargo of “new coronavirus antigen gene”

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After being delivered to human cells, “new coronavirus antigen gene” will neither self replicate nor have pathogenicity, but can express protein antigen of new coronavirus and stimulate human immune system to produce antibodies

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Wang Junzhi introduced that China’s self-developed adenovirus vector vaccine takes “type 5 adenovirus” as the carrier and introduces “new coronavirus antigen gene”, which can not only induce the production of neutralizing antibody, but also induce and enhance cellular immunity

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The current approved immunization procedure is single dose vaccination

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How to choose single needle and double needle? Shao Yiming said that for people who have temporary or urgent tasks to go to the epidemic area but do not have enough time to wait, it is more suitable to inject single dose adenovirus vector vaccine

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In addition, single dose adenovirus vector vaccine has the following advantages: first, single dose vaccination completes the whole process of immunization, avoids the immune shedding caused by long distance, busy work or lack of vaccine, and ensures high vaccination rate; second, the total cost of single dose injection is lower, and the cost-benefit ratio is higher; third, in the current global vaccine production capacity shortage situation In this case, a single dose of vaccine can reach twice as many people, which improves the accessibility of the vaccine

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However, there are both advantages and disadvantages

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Shao Yiming suggested that the intensity of immune response induced by single dose of adenovirus vector vaccine was generally weaker than that induced by two doses of vaccine

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Because when this kind of vaccine is vaccinated again, the human body mainly produces memory response to “car” – adenovirus vector, rather than “goods” – new coronavirus antigen gene

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This kind of single dose vaccine has no problem in the prevention of early epidemic virus, but when it is replaced by late mutant virus, the protection efficiency will mostly decline

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Therefore, when choosing vaccines, we should make comprehensive judgment and scientific decision according to the specific situation of the people to be protected and the latest monitoring data of local epidemic virus

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What are the contraindications to vaccination? 1

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Those with allergic reaction (such as acute allergic reaction, angioneurotic edema, dyspnea, etc.) can not be vaccinated

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2

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People who are allergic to vaccine ingredients and excipients can not be vaccinated

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The excipients of inactivated Xinguan vaccine mainly include: disodium hydrogen phosphate, sodium chloride, sodium dihydrogen phosphate and aluminum hydroxide

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3

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Allergic to dust mite, food (eggs, peanuts, seafood, Mango), pollen, alcohol, penicillin, cephalosporin or other drugs can be inoculated

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4

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In case of fever (axillary temperature ≥ 37.3 ℃) caused by any reason (cold, wound infection, local inflammation), the vaccination shall be postponed

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5

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In the acute stage of gout attack, severe cold, myocardial infarction and cerebral infarction, the vaccination should be postponed

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6

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Heart disease, coronary heart disease, coronary atherosclerosis and other diseases, not acute attack, can be vaccinated

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7

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The chronic patients with stable health and good drug control should not be regarded as the contraindication group of novel coronavirus vaccination, so vaccination is recommended

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8

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For patients with acute attack of chronic diseases or uncontrolled severe chronic diseases, vaccination should be postponed

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9

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The blood pressure is lower than 160 / 100mmhg and can be inoculated

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10

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Diabetes drug control is stable, fasting blood glucose ≤ 13.9mmol/l, can be inoculated

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11

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Patients with hypothyroidism can be vaccinated if they take the stabilizer dosage of levothyroxine (euthyrox) and their nail function is normal

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12

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Chronic eczema has no obvious attack and can be vaccinated

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13

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The current symptoms of chronic urticaria are not obvious and can be vaccinated

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14

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Chronic rhinitis symptoms are not obvious, can be vaccinated

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15

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Chronic hepatitis does not need to take medicine treatment, liver function is normal, can be vaccinated

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16

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Tuberculosis is not active and can be vaccinated

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17

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Psoriasis is non pustular and other acute types, which can be inoculated

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18

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COPD can be inoculated in non acute stage without obvious cough and asthma

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19

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Ankylosing spondylitis has no acute pain and can be inoculated

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20

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Depression drug control is good, life and work as usual, can be vaccinated

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21

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All kinds of drugs (including insulin injection) used for the treatment of diabetes are not contraindicated for vaccination

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22

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The patients with malignant tumor were undergoing chemotherapy and radiotherapy before and after operation, and the vaccination was postponed

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23

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The general principle of immune system diseases (systemic lupus erythematosus, rheumatoid arthritis, ankylosing spondylitis, Sjogren’s syndrome, etc.) is to be carefully vaccinated

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Generally speaking, when the condition is stable, we can be vaccinated with neocrown inactivated vaccine and recombinant subunit vaccine

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24

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Patients with malignant tumor who have not received chemotherapy or radiotherapy for more than three years after operation; nephrotic syndrome; immunosuppressive drugs after kidney transplantation; patients with AIDS and HIV infection should be vaccinated with inactivated vaccine and recombinant subunit vaccine

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25

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Patients with uncontrolled epilepsy and other serious nervous system diseases (such as transverse myelitis, Guillain Barre syndrome, demyelinating diseases, etc.) should be suspended from vaccination

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26

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During menstruation, pregnancy and lactation, vaccination can be carried out and lactation can be continued

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27

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No vaccination during pregnancy

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28

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It is not necessary to terminate pregnancy after vaccination

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It is recommended to do a good job in pregnancy examination and follow-up

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29

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There is no problem that men can not get the novel coronavirus vaccine because of pregnancy preparation

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30

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Novel coronavirus vaccine is not recommended to be inoculated with other vaccines at the same time

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The interval between other vaccines and novel coronavirus vaccine should be more than 14 days

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31

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In any case, when rabies vaccine, tetanus vaccine, rabies immunoglobulin and tetanus immunoglobulin need to be vaccinated due to animal injury, trauma and other reasons, the above vaccines and immunoglobulins shall be given priority regardless of the interval

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32

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If rabies vaccine, tetanus vaccine, rabies immunoglobulin, tetanus immunoglobulin, etc

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are inoculated first, the last dose of the above vaccines should be completed first, and the novel coronavirus vaccine can be inoculated after 14 days

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33

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The vaccination of human immunoglobulin should be carried out at least one month apart, so as not to affect the immune effect.

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