Vaccine | what’s the safety of xinguansanzhen vaccine? Is it more effective than two doses of vaccine?

News is the last week of April every year (April 24-30) is “world immunization week”, which aims to promote vaccination to protect people of all ages from disease

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The theme of this year’s world immunization week is “vaccines make us closer.”

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Reviewing the progress of medicine in disease prevention and treatment in the past century, vaccine can be called a miracle of modern medicine

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Even in 1974, only 5% of the world’s children completed the six vaccines recommended by the World Health Organization

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Since then, through international efforts, more than 80% of children have received basic vaccination

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Over the past 50 years, evidence has shown that vaccines have saved more lives than any other medical product or surgery

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Hundreds of years ago, some fatal infectious diseases spread around the world, and smallpox is one of the most serious

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On average, three out of every 10 people infected with smallpox die

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Fortunately, through the global campaign to eliminate smallpox, mankind successfully declared the elimination of the virus on the earth’s surface in 1977

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Smallpox is the only human infectious disease that can be eradicated through human efforts so far, and the vaccine has contributed a lot

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Hitherto unknown, there was no parallel in history

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Novel coronavirus pneumonia has been epidemic to date, but it has been more than a year ago

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It has caused irreparable damage to the whole world

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Scientists have also been involved in the prevention and control of the epidemic

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Vaccine development is an indispensable part of the disease

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The research and development of novel coronavirus vaccine has set a record in the history of vaccine research and development

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In one year, the whole process of vaccine research and development to marketing has been completed

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At present, the new coronavirus vaccine of five manufacturers in China has been approved for conditional marketing or emergency use“ The recombinant New Coronavirus vaccine (CHO cell) has been put into use in the urban area of Cangzhou, and has become an open vaccine after the inactivated vaccine

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How safe is this vaccine? Is there any difference with the effect of the vaccine injected before? What is the background of recombinant new coronavirus vaccine (CHO cells)? What kind of vaccine is this? At present, the recombinant new coronavirus vaccine (CHO cell) is jointly developed by Institute of Microbiology, Chinese Academy of Sciences and Anhui zhifeilongkema company (CHO cell is Chinese hamster ovary cell, which is widely used in the field of bioengineering and is the preferred cell for the production of protein drugs)

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This is the implementation of China’s third new vaccine technology route, and the first recombinant protein vaccine approved for mass vaccination in the world

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This kind of vaccine is prepared by DNA recombination technology, which only contains virus antigen protein RBD (receptor binding region) protein

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After inoculation, it can stimulate the body to produce immunity against new coronavirus, and can be used to prevent diseases caused by new coronavirus infection

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Second, there are many vaccines on the market in China

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Why should we develop this vaccine? Is it more effective than inactivated vaccine? Inactivated vaccine and recombinant vaccine have their own characteristics and advantages

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Inactivated vaccine novel coronavirus pneumonia has played an important role in the fight against novel coronavirus pneumonia, including large-scale use in China and abroad, which fully demonstrates the safety and efficacy of inactivated vaccine

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Inactivated vaccine is a kind of vaccine prepared by a series of purification techniques after killing the live virus by physical and chemical methods

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The main characteristics of the vaccine are that the composition of the vaccine is similar to that of the natural virus, the immune response is strong, and the vaccine has good safety; The vaccine is stable and can be stored at 2 ℃ to 8 ℃ for two to three years

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It is easy to transport

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Recombinant new coronavirus vaccine is to express the most effective antigen in vitro cells by genetic engineering

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In vitro cells are commonly used in biological products by engineering cell lines, similar to the way of industrial fermentation, and finally made into vaccines

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The whole production process is the process of protein expression and purification, without the participation of live virus, so the production process is safe and easy to large-scale production

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From the past use of recombinant protein vaccine and previous experimental results, the safety of recombinant protein vaccine can be guaranteed, and the incidence of adverse reactions is relatively low

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How about the safety and effectiveness of this vaccine? According to the results of existing clinical trials, the vaccine has good safety and effectiveness

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Most of the subjects had no adverse reactions, and a few of them had mild or moderate adverse reactions, mainly pain, dizziness or induration at the inoculation site

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The above adverse reactions were basically self-healing within 1 to 3 days

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The new coronal recombinant protein vaccine has also been studied in the elderly

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Although the neutralizing antibody level of the elderly is lower than that of the young adults, it is still within the effective range

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How many injections of recombinant new coronavirus vaccine do you need and how long is the interval? Go out to other places, there is no vaccine, follow-up vaccine can use other manufacturers? According to the national technical guidelines for new coronavirus vaccination (First Edition), three doses of recombinant new coronavirus vaccine were inoculated; It is suggested that the interval between the two adjacent doses should be more than 4 weeks, the second dose should be completed within 8 weeks after the first dose, and the third dose should be completed within 6 months after the first dose

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If this vaccine has not been given three times, it is not recommended to replace it with other kinds of vaccine (such as inactivated vaccine)

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Have you ever had a vaccine of the same technology before? The recombinant new coronavirus vaccine was expressed in CHO cells

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The outstanding representative of recombinant protein vaccine is hepatitis B vaccine, which has 30 years of production and use experience

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The rising stars include HPV vaccine (commonly known as cervical cancer vaccine) in 2006, recombinant protein influenza vaccine in 2013, hepatitis E vaccine in 2016 and recombinant protein herpes zoster vaccine in 2017

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These vaccines showed good safety and effectiveness in application

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As an RNA virus, neocoronavirus has a high probability of mutation in the process of replication

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When the mutation accumulates to a certain extent, it may affect the protection of the vaccine

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This risk exists

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In this regard, on the one hand, many scientific research institutions including China have begun to closely monitor, and actively carry out the research and development of new generation vaccine to deal with the new mutation

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On the other hand, the public should speed up vaccination and build up a group immune barrier as soon as possible

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Only when the number of infected people is significantly reduced, can the speed of virus mutation be reduced, and the epidemic situation be finally contained

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Whether the world can reopen depends on the accessibility and fairness of vaccines and the speed of promotion

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Global consensus and support for who to promote global vaccination will be the key point to end the pandemic as soon as possible..

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