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Please rest assured to pay attention At present, there are three kinds of vaccines available in China: inactivated vaccine, adenovirus vector vaccine and recombinant protein vaccine.
Among them, inactivated vaccine is very popular.
As long as two shots are given, what are the advantages and disadvantages of the three novel coronavirus vaccines in China? Which novel coronavirus vaccine has the best quality? 1、 What are the advantages and disadvantages of the three novel coronavirus vaccines in China? At present, there are three kinds of inactivated vaccine, adenovirus vector vaccine and recombinant protein vaccine in China, each of which has its own advantages and disadvantages.
The advantages and disadvantages of the three novel coronavirus vaccines in China are as follows: 1.
Advantages and disadvantages of the novel coronavirus inactivated vaccine: (1) advantages of the novel coronavirus inactivated vaccine: the preparation method is simple and rapid, and the safety is relatively high.
It is a common means to deal with the spread of acute diseases（ 2) Disadvantages of Xinguan inactivated vaccine: large vaccination dose, short immunization period and single immunization route.
The most terrible disadvantage is that it sometimes causes antibody dependent enhancement effect (ADE) and aggravates virus infection, which is a serious adverse reaction that will lead to the failure of vaccine research and development.
Advantages and disadvantages of the new coronal adenovirus vector vaccine (1) advantages of the new coronal adenovirus vector vaccine: it only needs one injection, can produce immune response faster, and has a protection rate of more than 60% in 14 days.
If you want to go abroad or perform tasks, the new coronal adenovirus vector vaccine is the first choice（ 2) Disadvantages of the new coronavirus vector vaccine: the response may be slightly larger.
Advantages and disadvantages of novel coronavirus recombinant protein vaccine (1) advantages of novel coronavirus recombinant protein vaccine: safe, efficient and large-scale production.
This route has a successful precedent.
The more successful genetic engineering subunit vaccine is hepatitis B surface antigen vaccine（ 2) Disadvantages of the novel coronavirus recombinant protein vaccine: its antigenicity is affected by the selected expression system, so the expression system needs to be carefully selected when preparing the vaccine.
2、 Which novel coronavirus vaccine has the best quality? The three novel coronavirus vaccines are of good quality, approved by the State Drug Administration, and have good safety and immune effect.
The differences of various vaccines are as follows: difference 1: different vaccination methods, adenovirus vector vaccine only needs one shot to be effective, inactivated vaccine needs two shots to be effective, and recombinant protein vaccine needs three shots to be effective.
Difference 2: different vaccine types.
The new coronavirus vector vaccine is one shot vaccine, the inactivated vaccine is two shots vaccine, and the new coronavirus recombinant protein vaccine is three shots vaccine.
Difference 3: the vaccination interval is different.
One shot of new coronavirus vector vaccine can be effective without another shot.
The vaccination interval between two doses of novel coronavirus inactivated vaccine is recommended to be 3-8 weeks.
The vaccination interval between two adjacent doses of novel coronavirus recombinant protein vaccine is recommended to be 4-8 weeks, and the third dose should be completed as far as possible 6 months after the first dose.
Difference four: novel coronavirus pneumonia vaccine protects Tianjin from 100% of the total protection rate, while the overall protection rate is 74.8%.
After two doses of inactivated vaccine, the protection rate was 79%; Zhifei recombinant protein novel coronavirus vaccine has not announced the specific protection efficiency, but it has a high protection rate against South African mutants.
Difference 5: different components (1) adenovirus vector vaccine uses human adenovirus type 5 (Ad5), which is widely used in recombinant gene therapy and vaccine vector（ 2) the novel coronavirus is the inactivated active ingredient of the inactivated vaccine.
The excipient is sodium hydrogen phosphate two (twelve water), sodium chloride, sodium dihydrogen phosphate (Monohydrate) and aluminum hydroxide adjuvant.
3) Recombinant protein vaccine uses transgenic technology to produce RBD protein on virus S protein, which can achieve high yield, high purity and low cost.
Difference 6: the production process is different.
Inactivated vaccine refers to culturing viruses or bacteria first, and then inactivating them with heating or chemical agent (usually formalin).
The whole production process of recombinant protein vaccine is a process of protein expression and purification.
It is a process without live virus.
The production process is relatively safe and can be produced on a large scale.
Conclusion: no matter which of the three novel coronavirus vaccines in China has its own advantages and disadvantages, but the quality is the best, so you can be assured of vaccination.
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