Source: Tess Andrade, the medical profession, may be one of the few people in the world who will not be infected by COVID-19.
Her husband was sent to the ICU for infection with the novel coronavirus.
She never wore a mask when she was at home with her husband.
She also has the experience of close contact with many newly diagnosed patients, but she has not been infected so far“ Tess’s two experiences show that some people may carry special genes and can avoid infection.
So is finding these genes equivalent to finding a way to defeat COVID-19? ” American health news website stat reports.
The day my husband was diagnosed with a novel coronavirus, “I went upstairs with my husband.
When he stepped on the last step, he suddenly collapsed to the ground.
” Tess Andrade recalled that it was a day in June 2020.
She quickly pulled out the portable pulse oximeter and put it on her husband’s fingertips“ He has a fever.
The equipment indicates that the blood oxygen level drops by 8 points compared with that in the morning.
” Tess has seen some studies that know that low blood oxygen is the main symptom of COVID-19 infection and progression to severe disease.
The purchase of oximeter is for “just in case”, self-monitoring and early detection at home.
Soon, his husband Eric’s oxygen saturation fell below 90%“ We can’t wait any longer.
I made an emergency call.
” Tess said that the CT after admission showed that Eric had multiple small patches and focal ground glass shadows in his lungs.
This means that there is a serious infection in the lungs.
The investigation of later contact history showed that Eric had visited a friend’s house seven days before the onset of symptoms.
His friend had been diagnosed with novel coronavirus infection before him.
Eric was soon transferred to the intensive care unit for mechanical ventilation.
After his condition was stable, he had a sudden thrombosis and his discharge time was delayed again and again“ It is worth noting that Tess.
She and her husband are very affectionate.
At home, they never wear masks, sleep in one bed and have a lot of intimate movements.
But Tess’s two novel coronavirus nucleic acid results were negative.
” Stat report.
This is not Tess’s only exposure to COVID-19.
She was invited to attend the conference at the University of Sao Paulo in Brazil.
After the meeting, many people were diagnosed with infection, and several were in close contact with Tess.
But Tess’s nucleic acid result was always negative“ It’s not just a matter of luck.
” Helen Su, an immunologist at the National Institute of allergy and infectious diseases, believes that the most terrible aspect of the novel coronavirus pandemic is that it is difficult to perfectly predict who will be infected and who will develop severe disease under the same conditions.
Photo caption: novel coronavirus pneumonia is being treated in a intensive care unit in California, us.
Does the Washington Post really have “innate immunity”? Even the most serious infectious diseases cannot “kill” infected people.
The 1918 pandemic influenza is one of the most deadly infectious diseases in human history.
It infected about 1 billion people worldwide from 1918 to 1919.
The mortality rate is estimated to be 2.5% – 5%, and most people can still recover from the epidemic“ Infectious diseases or special genetic loopholes make people more susceptible to certain pathogens.
But these deadly genetic traits will not be noticed until the pathogen ‘exploits’ into the human body.
” Jean Laurent Casanova of Rockefeller University in New York and Nike children’s Hospital in Paris, France, told stat.
In 1952, an 8-year-old boy was admitted to Walter Reed Army Hospital in Washington.
The little boy had recurrent infection, and the effect of antibiotic treatment was not ideal.
Through protein electrophoresis, the attending doctor found that he was congenital lack of serum globulin.
After injecting serum globulin once a month, the boy’s health improved significantly and lived to adulthood.
Since then, this primary immunodeficiency has been referred to as X-linked agammaglobulinemia (XLA).
So far, more than 400 “innate errors of immunity” have been recorded.
Over the past 25 years, Casanova has continued to collect and analyze the genomes of children, adolescents and young people.
He found that some young people infected with herpes simplex virus and varicella zoster virus have more severe symptoms and longer recovery time.
Some children never show low immunity, but are repeatedly infected with a single pathogen.
At the same time, the medical and scientific circles also continue to find some innate “characteristics” that can “immune” to a certain disease.
Among them, the most famous is Stephen Krohn, who will never be infected with AIDS.
In 1978, croon’s companion, gymnast Jerry Green, was diagnosed with AIDS.
10 years after Green died of illness, more than 70 friends of Crohn died of AIDS.
Only Crohn is always healthy.
He kept telling family members, “we must have some kind of natural antibody.” In the mid-1990s, this conjecture was confirmed: Crohn carried a CCR5-delta32 gene mutation.
CCR5 is a protein on the surface of human immune cells.
HIV must combine with CCR5 to get into human cells and cause infection.
The CCR5 mutation is equivalent to closing the passage of HIV into the human body.
Research shows that less than 1% of the world’s population carries this mutant gene“ The essence of infectious diseases may be genetic diseases.
This has led to a change in the diagnosis and treatment paradigm of infectious diseases.
” Cassanova told stat.
The genomes of more than 100000 novel coronavirus patients have been analyzed, and Maya zaz, director of the human genome research center of the University of Sao Paulo in Brazil, has been studying “genetic genes against viral infection”.
In 2018, she published a study involving nine pairs of twins.
Seven of them are heterozygous and two are homozygous.
The children’s mothers were infected with Zika virus during pregnancy.
But it was clearly raised in a womb.
One child was diagnosed with congenital Zika syndrome such as microcephaly at birth, while the other was very healthy.
Further analysis showed that human susceptibility to Zika virus was related to its genetic background, and the key was whether neural progenitor cells would be infected.
Some cells are difficult to be infected due to the lack of cell surface glycoprotein CD24.
In February 2020, zaz passed the residence of a middle-aged couple while walking.
She realized that she hadn’t seen the host for days.
When asked, the man was infected with the novel coronavirus and hospitalized, but his wife was fine“ Novel coronavirus virus or natural immunity.
We can apply the idea of twins research to close partners, and isolate and identify the genes that resist COVID-19.
With this idea, a few days later, zaz accepted an interview with Brazilian television and invited couples to sign up for relevant research.
She and her research team received 3000 emails, and eventually 100 couples were selected and sequenced.
These couples are infected and have symptoms on one side, but the novel coronavirus nucleic acid result of the other side is negative《 In July 2021, the Journal of nature issued a document that the international cooperation program “COVID-19 human genetics research” (Covid-19HumanGeneticEffort) has been launched for over 1 years.
The research team around the world has analyzed and interpreted the genome of 10 000 novel coronavirus patients, and found that there are statistically strong correlations between a dozen genetic mutations and the risk of individual infection and severe illness.
The first “type 1 interferon” to be found.
In the 1960s, scientists found that human cells had an internal alarm system.
When the virus invades, the infected cells will generate “type 1 interferon” protein and release it outside the cells to inform the body of “attack and start immune protection”.
However, genetic defects will lead to the failure of “type 1 interferon” production.
This is equivalent to silencing the alarm.
Then, the virus will multiply rapidly in the body.
A study published in September 2020 showed that about 3.5% of newly diagnosed patients had gene mutations, making them unable to produce “type 1 interferon”..