26% of novel coronavirus patients have mental symptoms? There were still problems 12 months after discharge, and the sequelae data of the

Wen / Wendy   Ifeng.com, a specialist in the Department of oncology intelligence, the US Center for physicians and the doctor of Biomedical Sciences, said that between 1.

and September 1, 2021, COVID-19 had caused 218 million infections and 4 million 520 thousand deaths worldwide.

It is estimated that nearly 10% of the novel coronavirus rehabilitation patients in the world suffer from different new post crown symptoms.

According to the latest study of the lancet, 1276 novel coronavirus patients hospitalized in Wuhan Jinyintan hospital in early 2020 still have mainstream sequelae such as myasthenia / fatigue, depression / anxiety, dyspnea, sleep difficulties, hair loss and joint pain 12 months after discharge.


The study showed that although the symptoms of patients with novel coronavirus improved after half a year, the proportion of patients with dyspnea, anxiety and depression increased.

In addition, similar to SARS’s sequelae, fatigue or muscle weakness are the most common symptoms of novel coronavirus patients.


There are still three characteristics and five problems in the sequelae of the novel coronavirus.

First, the sequelae of the novel coronavirus is named and promoted by the patient; Second, the sequelae of the novel coronavirus is a melting pot of various symptoms; Third, the sequelae of the novel coronavirus need interdisciplinary comprehensive treatment.

In addition, the sequelae of the novel coronavirus still have some problems, such as unclear academic definition, many and complex symptoms and so on.

Prevention of novel coronavirus infection is the best way to prevent its sequelae.

Myasthenia, dyspnea, and 12 months after discharge were still symptomatic.

Wuhan’s gold and silver hospital released the largest and longest sequelae of data so far.

By September 1, 2021, COVID-19 had caused 218 million infections and 4 million 520 thousand deaths worldwide.

With the global persistence of the covid-19 pandemic, the emerging challenge in medicine is to shift from dealing with acute infection to dealing with the burden on the medical system caused by the long-term consequences of the novel coronavirus.

It is estimated that about 10% of the novel coronavirus rehabilitation patients worldwide suffer from different novel coronavirus sequelae.

According to the data on the official website of the National Health Commission on August 31, 94879 confirmed cases and 4636 deaths have been reported in China.

89145 discharged cases were cured.

How many of the 89145 confirmed and cured discharged cases suffer from the sequelae of the novel coronavirus, and how are they recovering? What are the symptoms of these novel coronavirus sequelae? On August 28, the lancet, a famous international medical journal, published a new study on the sequelae of patients with novel coronaviruss in China.

This is the largest one-year follow-up at present.

It evaluates the health status of 1276 novel coronavirus patients hospitalized in Wuhan Jinyintan hospital in early 2020, 12 months after discharge, and provides the latest data on the situation of domestic novel coronavirus sequelae patients.

This paper shows that 12 months after the 1276 novel coronavirus patients were discharged from the hospital, there are still: – 30% dyspnea – 26% depression / anxiety – 12% did not return to work before the disease.

There are 205 symptoms of sequelae of novel coronaviruss abroad.

How many in China? This paper shows that muscle weakness / fatigue, depression / anxiety, dyspnea, sleep difficulties, hair loss and joint pain are the mainstream sequelae of follow-up patients so far.

Fatigue or muscle weakness after Xinguan disease seems insignificant.

In fact, it is chronic and long-term fatigue.

Many people also feel uncomfortable after fatigue, that is, the symptoms will worsen after physical or mental consumption, which will seriously affect the life of patients.

Some people are unable to work or dare not go out.

In addition, according to the relevant data of this research article, if the excluded 56 patients with mental problems / dementia who cannot participate in the follow-up are also partially taken into account, the proportion of people with mental symptoms is actually higher.

The study was a longitudinal cohort study led by Cao Bin, Department of respiratory and critical medicine, China Japan Friendship Hospital, Wang Xianguang, Wuhan Jinyintan hospital, and Wang Jianwei, national respiratory medicine center and Chinese Academy of Medical Sciences.

Cao Bin’s team had previously published the follow-up of the same group of patients at 6 months in the lancet (January 2021).

At that time, they found that about three-quarters of the novel coronavirus survivors still had persistent symptoms after discharge.

Patients with critical conditions during hospitalization were more likely to have pulmonary gas diffusion disorder and imaging abnormalities than patients with lower disease severity.

This paper is a two-way cohort study of Xinguan survivors discharged from Wuhan Jinyintan hospital in the early stage of the epidemic.

In short, all 2469 novel coronavirus patients discharged from Jinyintan hospital from January 7 to May 29, 2020 are eligible to participate.

If the patient dies after discharge; Living in a nursing home or welfare home; Mental problems, dementia or osteoarthropathy; Or inconvenient to move.

Patients were followed up at 6 and 12 months after discharge.

Finally, a total of 1276 patients with novel coronaviruss completed two follow-up visits, with a median age of 59 years.

Among these patients, the proportion of men and participants receiving oxygen treatment during hospitalization was slightly higher than that of non included patients.

There were no significant differences between the two groups in age, smoking status, complications and access to intensive care unit.

During each follow-up, the patients received detailed interview, physical examination and 6-minute walking test, and also answered various questionnaires to reflect their dyspnea, quality of life, medical treatment after discharge, etc.

The researchers randomly selected patients for pulmonary function examination and chest CT at 6 months, and rechecked at 12 months as needed.

In order to determine whether the novel coronavirus patients fully recovered at 12 months, the researchers recruited community adults who had not been infected with the novel coronavirus from Wuhan as the control group from December 24, 2020 to January 16, 2021.

The novel coronavirus survivors and the control group were further matched 1:1 according to age, gender and basic diseases.

The members of the control group were interviewed face-to-face by the medical staff of Jinyintan hospital in the community, underwent physical examination, and filled in various questionnaires similar to the patients.

According to foreign statistics, there are 205 sequelae symptoms of novel coronaviruss.

How many symptoms are there in China? Some symptoms are similar to those of SARS? This study shows that some symptoms of patients have been significantly improved: 1.

The proportion of patients with at least one sequelae symptom decreased from 68% at 6 months to 49% at 12 months (P < 0.0001).


Fatigue or muscle weakness were the most common symptoms at the two visits, but the proportion decreased from 52% at 6 months to 20% at 12 months (P < 0.0001).

The improvement of these two common symptoms is very obvious, and some other symptoms subside over time, such as difficulty sleeping, hair loss, smell and taste disorders.

The causes and pathogenesis of fatigue and myasthenia after novel coronavirus are not yet clear, but according to previous studies on SARS, the damage of lung gas diffusion capacity, muscle inflammation, cytokine disorder, muscle atrophy and weakness, or corticosteroid myopathy, or combinations of these factors were all possible causes.


Among the patients who had work before the disease, 88% resumed their original work after 12 months, and 3 / 4 of them have returned to the work level before the novel coronavirus.

Among the remaining 12% of patients who did not return to their original work, 32% were due to decreased physical function, 25% because they were unwilling to do their previous work and 18% because they were unemployed.

This large-scale follow-up study also exposed some problems that need to be considered: 1.

The proportion of patients with dyspnea increased slightly from 26% at 6 months to 30% at 12 months.

2 (P = 0.014).

After half a year, the proportion of dyspnea has not decreased, but more than 6 months, which deserves attention.

Previous studies have pointed out that Xinguan survivors use more bronchodilators, anti cold drugs, expectorants, antidepressants and anti anxiety drugs after recovery..